Cognitive, Sensory, and Motor Impairments Associated with Aluminium, Manganese, Mercury and Lead Exposures in the Onset of Neurodegeneration
Chinyere Dike1,2, Mfoniso Antia1, Bolaji Bababtunde1,2, Anthonet Ezejiofor1,3 and Francis Sikoki1,2
1Africa Centre of Excellence, Centre for Public Health and Toxicological Research (ACE-PUTOR) University of Port Harcourt, PMB, Port Harcourt, Choba 5323, Nigeria.
2Department of Animal and Environmental Biology, Faculty of Science, University of Port Harcourt, PMB, Port Harcourt, Choba 5323, Nigeria.
3Department of Experimental Pharmacology & Toxicology, Faculty of Pharmacy, University of Port Harcourt, PMB, Port Harcourt, Choba 5323, Nigeria.
DOI: https://doi.org/10.54117/ijph.v2i1.9
Keywords: Neurodegenerative disease, behavioural alterations, neurotoxicity, heavy metals
Abstract
Neurobehavioral investigations are essential for assessing the risk of heavy metal toxicity. This review provides a general overview of the cognitive and motor consequences associated with Al, Mn, Hg, and Pb exposure during early life as well as during adult stage in the onset of neurodegenerative diseases. This review showed that heavy metal exposure in early life results in more impacts due to the vulnerability of the blood brain barrier. The effects of Al, Mn, Hg, and Pb includes defects in habituation, decreased in rearing activity; intense defecation, motor impairments, decreased spatial memory and performance; declines in reference, recognition and working memory. It also causes an increase in the number of errors, an increase in the time it takes to find the platform, an increase in swimming distance, and a decrease in step-through latency and many others. Hence, Heavy metals are acknowledged inducers of behavioural toxicity and serve as sensitive endpoints of chemically produced neurotoxicity.