Comparative Assessment of Adverse Effects of Synergistic Combination of Pyrimethamine and Sulfadoxine (Fansidar/Maloxine) in Patients Studied in Abakaliki, Ebonyi State, Nigeria
Authors
I.M. Ikeh, Department of Zoology, Nnamdi Azikiwe University Awka, Anambra State, Nigeria
O.O. Odikamnoro, Department of App. Biology, Ebonyi State University Abakaliki
V.O. Okonkwo, Department of Zoology, Nnamdi Azikiwe University Awka, Anambra State, Nigeria
I.O. Nnatuanya, Department of Zoology, Nnamdi Azikiwe University Awka, Anambra State, Nigeria
How to Cite
Ikeh, I., Odikamnoro, O., Okonkwo, V., & Nnatuanya , I. (2021). Comparative Assessment of Adverse Effects of Synergistic Combination of Pyrimethamine and Sulfadoxine (Fansidar/Maloxine) in Patients Studied in Abakaliki, Ebonyi State, Nigeria. Tropical Journal of Applied Natural Sciences (TJANS), 3(2), 14–18. https://doi.org/10.25240/tjans.v3i2.3
Abstract
Adverse effects of antimalarial drugs, which were commonly attributed to chloroquine such as: headache, various skin eruptions, Pruritus, Gastro-intestinal disturbances such as nausea, and vomiting. Others include mental changes involving psychotic episodes, anxiety, visual disturbances such as blurred vision, keratopathy or retinopathy. Some common side effects like loss of hair, ototoxicity, photosensitivity, tinnitus, neuro-myopathy, myopathy, erythema multiformes and Stevens-Johnson syndrome, hemolysis and blood dyscrasias, Neutropenia etc., are still reported in some patients treated with the Pyrimethamine and Sulphadoxine drug combination. The emergence of combination therapeutic approach to malaria treatment was believed to have reduced the frequency of these events, but most, still persist. This survey was conducted to therefore assess the overall presentation of Diarrhoea, Pruritus and Vomit in Patients treated with Maloxine and Fansidar. At Day zero, (D0), 40(15.0%) Presented positive Diarrhoea cases; 05(1.9%) present positive cases of pruritus and 73(27.4%) presented positive cases of vomit. At Day 2, (D2), 03(1.1%) presented positive Diarrhoea cases as against 263(98.9%) of negative cases; 01(0.4%) presented positive cases of pruritus as against 265(99.6%) of negative cases. Day Seven, (D7) and Day Fourteen, (D14) recorded clearance of the adverse effects. There is therefore need for relevant drug treatment follow up to clear the adverse effects engendered by malaria drug therapy.
Keywords: Synergistic, Pyrimethamine, Sulphadoxine, Diarrhoea, Pruritus